Kim JW, Kim S. Lee H. Cho G. Kim SC, Lee H, Jin MS, Lee J-O (2019) Application of anti-helix antibodies in protein structure determination. Proc Natl Acad Sci U S A. 116, 17786-17791.

63.

An H-J, Ryu M, Jeong HJ, Kang M. Jeon, H-M, Lee J-O, Kim YS, Lee H. (2019) Higd-1a Regulates the proliferation of pancreatic cancer cells through a pERK/p27KIP1/pRB pathway. Cancer Lett. 461, 78-89.

62.

Lee EB, Jeon,H-M, Kim, C-U, Park, SM, Cho G., Kim H-J, Kim Y., Kim D-J, Kim, Y-S, Lee, H, and Lee J-O (2019) Attachment of flagellin enhances the immunostimulatory activity of a hemagglutinin-ferritin nano-cage, Nanomed.-Nanotechnol. Biol. Med. 17, 223-235

61.

Kwon NY, Kim Y. Lee, J-O. (2019) Structural diversity and flexibility of diabodies. Methods. 154, 136-142.

60.

Kim JH and Lee J-O (2018) Application of helix fusion method in structural biology. Biodesign. 6 (1), 10-14.

59.

Kim, J. A., Kim, D., Won, S. Y., Han, K. A., Park, D., Cho, E., Yun, N., An, H. J., Um, J. W., Kim, E., Lee, J.-O., Ko, J. & Kim, H. M. Structural Insights into Modulation of Neurexin-Neuroligin Trans -synaptic Adhesion by MDGA1/Neuroligin-2 Complex. Neuron 94, 1121–1131.e6 (2017).

58.

Lee, H. K., Kim, M.-K., Kim, H. D., Kim, H. J., Kim, J. W., Lee, J.-O., Kim, C.-W. & Kim, E. E. Unique binding mode of Evogliptin with human dipeptidyl peptidase IV. Biochemical and Biophysical Research Communications 494, 452–459 (2017).

57.

Youn, S.-J., Kwon, N.-Y., Lee, J. H., Kim, J. H., Choi, J., Lee, H. & Lee, J.-O. Construction of novel repeat proteins with rigid and predictable structures using a shared helix method. Scientific Reports 7, (2017).

56.

Kim, J. W., Kim, S., Kim, S., Lee, H., Lee, J.-O. & Jin, M. S. Structural insights into the elevator-like mechanism of the sodium/citrate symporter CitS. Scientific Reports 7, (2017).

55.

Won, S. Y., Kim, C. Y., Kim, D., Ko, J., Um, J. W., Lee, S. B., Buck, M., Kim, E., Heo, W. D., Lee, J.-O. & Kim, H. M. LAR-RPTP Clustering Is Modulated by Competitive Binding between Synaptic Adhesion Partners and Heparan Sulfate. Frontiers in Molecular Neuroscience 10,(2017).

54.

Ryu, J.-K., Kim, S. J., Rah, S.-H., Kang, J. I., Jung, H. E., Lee, D., Lee, H. K., Lee, J.-O., Park, B. S., Yoon, T.-Y. & Kim, H. M. Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer. Immunity 46, 38–50 (2017).

53.

Jeong, W. H., Lee, H., Song, D. H., Eom, J.-H., Kim, S. C., Lee, H.-S., Lee, H. & Lee, J.-O. Connecting two proteins using a fusion alpha helix stabilized by a chemical cross linker. Nature Communications 7, (2016).

52.

Kim, J. H., Song, D. H., Youn, S.-J., Kim, J. W., Cho, G., Kim, S. C., Lee, H., Jin, M. S. & Lee, J.-O. Crystal structures of mono- and bi-specific diabodies and reduction of their structural flexibility by introduction of disulfide bridges at the Fv interface. Scientific Reports 6,(2016).

51.

Kim, H., Youn, S.-J., Kim, S. O., Ko, J., Lee, J.-O. & Choi, B.-S. Structural Studies of Potassium Transport Protein KtrA Regulator of Conductance of K+(RCK) C Domain in Complex with Cyclic Diadenosine Monophosphate (c-di-AMP). Journal of Biological Chemistry290, 16393–16402 (2015).

50.

Hwang, J., Suh, H.-W., Jeon, Y. H., Hwang, E., Nguyen, L. T., Yeom, J., Lee, S.-G., Lee, C., Kim, K. J., Kang, B. S., Jeong, J.-O., Oh, T.-K., Choi, I., Lee, J.-O. & Kim, M. H. The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein. Nature Communications 5, (2014).

49.

Um, J. W., Kim, K. H., Park, B. S., Choi, Y., Kim, D., Kim, C. Y., Kim, S. J., Kim, M., Ko, J. S., Lee, S.-G., Choii, G., Nam, J., Heo, W. D., Kim, E., Lee, J.-O., Ko, J. & Kim, H. M. Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion. Nature Communications 5,(2014).

48.

Eckert, J. K., Kim, Y. J., Kim, J. I., Gürtler, K., Oh, D.-Y., Sur, S., Lundvall, L., Hamann, L., van der Ploeg, A., Pickkers, P., Giamarellos-Bourboulis, E., Kubarenko, A. V., Weber, A. N., Kabesch, M., Kumpf, O., An, H.-J., Lee, J.-O. & Schumann, R. R. The Crystal Structure of Lipopolysaccharide Binding Protein Reveals the Location of a Frequent Mutation that Impairs Innate Immunity. Immunity 39, 647–660 (2013).

47.

An, H.-J., Cho, G., Lee, J.-O., Paik, S.-G., Kim, Y. S. & Lee, H. Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria. Proceedings of the National Academy of Sciences 110, 13014–13019 (2013).

46.

Liu, D., Ryu, K.-S., Ko, J., Sun, D., Lim, K., Lee, J.-O., Hwang, J. m., Lee, Z. -w. & Choi, B.-S. Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain. Journal of Molecular Cell Biology 5, 204–206 (2012).

45.

Park, B. S. & Lee, J.-O. Recognition of lipopolysaccharide pattern by TLR4 complexes. Experimental & Molecular Medicine 45, e66–e66 (2013).

44.

Hwang, J., Kim, B. S., Jang, S. Y., Lim, J. G., You, D.-J., Jung, H. S., Oh, T.-K., Lee, J.-O., Choi, S. H. & Kim, M. H. Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. Proceedings of the National Academy of Sciences 110, E2829–E2837 (2013).

43.

Song, D. H. & Lee, J.-O. Sensing of microbial molecular patterns by Toll-like receptors. Immunological Reviews 250, 216–229 (2012).

42.

Kim, S. O., Yoon, H., Park, S. O., Lee, M., Shin, J.-S., Ryu, K.-S., Lee, J.-O., Seo, Y.-S., Jung, H. S. & Choi, B.-S. Srs2 possesses a non-canonical PIP box in front of its SBM for precise recognition of SUMOylated PCNA. Journal of Molecular Cell Biology 4, 258–261 (2012).

41.

An, H.-J., Shin, H., Jo, S.-G., Kim, Y. J., Lee, J.-O., Paik, S.-G. & Lee, H. The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813, 2088–2098 (2011).

40.

Kang, J. Y. & Lee, J.-O. Structural Biology of the Toll-Like Receptor Family. Annual Review of Biochemistry 80, 917–941 (2011).

39.

Hwang, J., Kim, Y., Kang, H. B., Jaroszewski, L., Deacon, A. M., Lee, H., Choi, W.-C., Kim, K.-J., Kim, C.-H., Kang, B. S., Lee, J.-O., Oh, T.-K., Kim, J. W., Wilson, I. A. & Kim, M. H. Crystal Structure of the Human N-Myc Downstream-regulated Gene 2 Protein Provides Insight into Its Role as a Tumor Suppressor. Journal of Biological Chemistry 286, 12450–12460 (2011).

38.

An, H.-J., Kim, Y. J., Song, D. H., Park, B. S., Kim, H. M., Lee, J. D., Paik, S.-G., Lee, J.-O. & Lee, H. Crystallographic and Mutational Analysis of the CD40-CD154 Complex and Its Implications for Receptor Activation. Journal of Biological Chemistry 286, 11226–11235 (2011).

37.

Park, W. S., Kang, S. K., Jun, M. A., Shin, M. S., Kim, K. Y., Rhee, S. D., Bae, M. A., Kim, M. S., Kim, K. R., Kang, N. S., Yoo, S., Lee, J. O., Song, D. H., Silinski, P., Schneider, S. E., Ahn, J. H. & Kim, S. S. Discovery of β-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 21, 1366–1370 (2011).

36.

Ko, J., Ryu, K.-S., Kim, H., Shin, J.-S., Lee, J.-O., Cheong, C. & Choi, B.-S. Structure of PP4397 Reveals the Molecular Basis for Different c-di-GMP Binding Modes by Pilz Domain Proteins. Journal of Molecular Biology 398, 97–110 (2010).

35.

Kang, J. Y., Nan, X., Jin, M. S., Youn, S.-J., Ryu, Y. H., Mah, S., Han, S. H., Lee, H., Paik, S.-G. & Lee, J.-O. Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer. Immunity 31, 873–884 (2009).

34.

Ryu, K.-S., Lee, J.-O., Kwon, T. H., Choi, H.-H., Park, H.-S., Hwang, S. K., Lee, Z.-W., Lee, K.-B., Han, Y. H., Choi, Y.-S., Jeon, Y. H., Cheong, C. & Kim, S. The presence of monoglucosylated N196-glycan is important for the structural stability of storage protein, arylphorin. Biochemical Journal 421, 87–96 (2009).

33.

Jung, K., Lee, J.-E., Kim, H.-Z., Kim, H. M., Park, B. S., Hwang, S.-I., Lee, J.-O., Kim, S. C. & Koh, G. Y. Toll-Like Receptor 4 Decoy, TOY, Attenuates Gram-Negative Bacterial Sepsis. PLoS ONE 4, e7403 (2009).

32.

Park, B. S., Song, D. H., Kim, H. M., Choi, B.-S., Lee, H. & Lee, J.-O. The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex. Nature 458, 1191–1195 (2009).

31.

Jin, M. S. & Lee, J. Ligand recognition by the toll‐like receptor family. Animal Cells and Systems 13, 1–8 (2009).

30.

Ahn, J. H., Park, W. S., Jun, M. A., Shin, M. S., Kang, S. K., Kim, K. Y., Rhee, S. D., Bae, M. A., Kim, K. R., Kim, S. G., Kim, S. Y., Sohn, S. K., Kang, N. S., Lee, J. O., Lee, D. H., Cheon, H. G. & Kim, S. S. Synthesis and biological evaluation of homopiperazine derivatives with β-aminoacyl group as dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 18, 6525–6529 (2008).

29.

Jun, M. A., Park, W. S., Kang, S. K., Kim, K. Y., Kim, K. R., Rhee, S. D., Bae, M. A., Kang, N. S., Sohn, S.-K. & Kim, S. G. Synthesis and biological evaluation of pyrazoline analogues with β-amino acyl group as dipeptidyl peptidase IV inhibitors. European Journal of Medicinal Chemistry 43, 1889–1902 (2008).

28.

Jin, M. S. & Lee, J.-O. Structures of TLR–ligand complexes. Current Opinion in Immunology 20, 414–419 (2008).

27.

Jin, M. S. & Lee, J.-O. Structures of the Toll-like Receptor Family and Its Ligand Complexes. Immunity 29, 182–191 (2008).

26.

Lee, K. E., Kim, H. M., Lee, J.-O., Jeon, H. & Han, S. S. Regulation of CD40 reconstitution into a liposome using different ratios of solubilized LDAO to lipids. Colloids and Surfaces B: Biointerfaces 62, 51–57 (2008).

25.

Jin, M. S., Kim, S. E., Heo, J. Y., Lee, M. E., Kim, H. M., Paik, S.-G., Lee, H. & Lee, J.-O. Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide. Cell 130, 1071–1082 (2007).

24.

Hwang, E., Ryu, K.-S., Paakkonen, K., Guntert, P., Cheong, H.-K., Lim, D.-S., Lee, J.-O., Jeon, Y. H. & Cheong, C. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proceedings of the National Academy of Sciences 104, 9236–9241 (2007).

23.

Kim, H. M., Park, B. S., Kim, J.-I., Kim, S. E., Lee, J., Oh, S. C., Enkhbayar, P., Matsushima, N., Lee, H., Yoo, O. J. & Lee, J.-O. Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran. Cell 130, 906–917 (2007).

22.

Yoon, M.-K., Kim, H.-M., Choi, G., Lee, J.-O. & Choi, B.-S. Structural Basis for the Conformational Integrity of theArabidopsis thalianaHY5 Leucine Zipper Homodimer. Journal of Biological Chemistry 282, 12989–13002 (2007).

21.

Ahn, J. H., Shin, M. S., Jun, M. A., Jung, S. H., Kang, S. K., Kim, K. R., Rhee, S. D., Kang, N. S., Kim, S. Y., Sohn, S.-K., Kim, S. G., Jin, M. S., Lee, J. O., Cheon, H. G. & Kim, S. S. Synthesis, biological evaluation and structural determination of β-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors. Bioorganic & Medicinal Chemistry Letters 17, 2622–2628 (2007).

20.

Kim, H. M., Oh, S. C., Lim, K. J., Kasamatsu, J., Heo, J. Y., Park, B. S., Lee, H., Yoo, O. J., Kasahara, M. & Lee, J.-O. Structural Diversity of the Hagfish Variable Lymphocyte Receptors. Journal of Biological Chemistry 282, 6726–6732 (2006).

19.

An, H.-J., Maeng, O., Kang, K.-H., Lee, J.-O., Kim, Y.-S., Paik, S.-G. & Lee, H. Activation of Ras Up-regulates Pro-apoptotic BNIP3 in Nitric Oxide-induced Cell Death. Journal of Biological Chemistry 281, 33939–33948 (2006).

18.

Oh, H. J., Lee, K.-K., Song, S. J., Jin, M. S., Song, M. S., Lee, J. H., Im, C. R., Lee, J.-O., Yonehara, S. & Lim, D.-S. Role of the Tumor Suppressor RASSF1A in Mst1-Mediated Apoptosis. Cancer Research 66, 2562–2569 (2006).

17.

An, S., Cho, K.-H., Lee, W. S., Lee, J.-O., Paik, Y.-K. & Jeong, T.-S. A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: Evidence for catalytic difference between ACAT1 and ACAT2. FEBS Letters 580, 2741–2749 (2006).

16.

Ryu, K.-S., Kim, J.-I., Cho, S.-J., Park, D., Park, C., Cheong, H.-K., Lee, J.-O. & Choi, B.-S. Structural Insights into the Monosaccharide Specificity of Escherichia coli Rhamnose Mutarotase. Journal of Molecular Biology 349, 153–162 (2005).

15.

Kim, J.-I., Lee, C. J., Jin, M. S., Lee, C.-H., Paik, S.-G., Lee, H. & Lee, J.-O. Crystal Structure of CD14 and Its Implications for Lipopolysaccharide Signaling. Journal of Biological Chemistry 280, 11347–11351 (2005).

14.

Yook, Y.-H., Kang, K.-H., Maeng, O., Kim, T.-R., Lee, J.-O., Kang, K., Kim, Y. S., Paik, S.-G. & Lee, H. Nitric oxide induces BNIP3 expression that causes cell death in macrophages. Biochemical and Biophysical Research Communications 321, 298–305 (2004).

13.

Maeng, O., Kim, Y. C., Shin, H.-J., Lee, J.-O., Huh, T.-L., Kang, K., Kim, Y. S., Paik, S.-G. & Lee, H. Cytosolic NADP+-dependent isocitrate dehydrogenase protects macrophages from LPS-induced nitric oxide and reactive oxygen species. Biochemical and Biophysical Research Communications 317, 558–564 (2004).

12.

Zhukovsky, E. A., Lee, J.-O., Villegas, M., Chan, C., Chu, S. & Mroske, C. Is TALL-1 a trimer or a virus-like cluster? Nature 427, 413–414 (2004).

11.

Sung, B.-J., Yeon Hwang, K., Ho Jeon, Y., Lee, J. I., Heo, Y.-S., Hwan Kim, J., Moon, J., Min Yoon, J., Hyun, Y.-L., Kim, E., Jin Eum, S., Park, S.-Y., Lee, J.-O., Gyu Lee, T., Ro, S. & Myung Cho, J. Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. Nature 425, 98–102 (2003).

10.

Kim, H. M., Shin, D. R., Yoo, O. J., Lee, H. & Lee, J.-O. Crystal structure of Drosophila  angiotensin I-converting enzyme bound to captopril and lisinopril1. FEBS Letters 538, 

65–70 (2003).

9.

Kim, H. M., Yu, K. S., Lee, M. E., Shin, D. R., Kim, Y. S., Paik, S.-G., Yoo, O. J., Lee, H. & Lee, J.-O. Crystal structure of the BAFF–BAFF-R complex and its implications for receptor activation. Nature Structural & Molecular Biology 10, 342–348 (2003).

8.

Lee, M. E., Markowitz, J., Lee, J.-O. & Lee, H. Crystal structure of phosphodiesterase 4D and inhibitor complex1. FEBS Letters 530,53–58 (2002).

7.

Lee, J.-O., Yang, H., Georgescu, M.-M., Di Cristofano, A., Maehama, T., Shi, Y., Dixon, J. E., Pandolfi, P. & Pavletich, N. P. Crystal Structure of the PTEN Tumor Suppressor. Cell 99, 323–334 (1999).

6.

Bardwell, J. C., Lee, J. O., Jander, G., Martin, N., Belin, D. & Beckwith, J. A pathway for disulfide bond formation in vivo. Proceedings of the National Academy of Sciences 90, 1038–1042 (1993).

5.

Russo, A. A., Tong, L., Lee, J.-O., Jeffrey, P. D. & Pavletich, N. P. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature 395, 237–243 (1998).

4.

Lee, J.-O., Russo, A. A. & Pavletich, N. P. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 391, 859–865 (1998).

3.

Lee, J.-O., Rieu, P., Arnaout, M. A. & Liddington, R. Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18). Cell 80, 631–638 (1995).

2.

Lee, J.-O., Bankston, L. A. & Robert C Liddington, M. A. A. and. Two conformations of the integrin A-domain (I-domain): a pathway for activation Structure 3, 1333–1340 (1995).

1.

 Antibody Structure and Engineering Lab, 항체구조생물학 연구실

Dept. of Life Sciences, Pohang University of Science and Technology

Tel (Lab) : +82-54-279-2323/ Office : +82-54-279-2323